Finding method in madness
Researchers link suicide to brain chemicals
November 15, 1996
Web posted at: 11:40 p.m. EST
From Correspondent Eugenia Halsey
WASHINGTON (CNN) -- Every year, 30,000 people in the United
States commit suicide.
Now, predicting who will do so may not be the mystery
previously thought. Certain chemicals in the brain seem to
play a role, scientists are saying.
New studies indicate that people who commit suicide have
something in common: not enough serotonin, a brain chemical
that controls mood.
Serotonin normally helps people restrain their impulses.
Without enough of the chemical, they may act on their
suicidal thoughts.
This shows psychiatric illnesses and suicide are brain-
related disorders, researchers say.
"They're not just a function of the vagaries of everyday
life," said John Mann of Columbia University. "People don't
go out and kill themselves just because they've lost their
job."
In Washington, at a workshop on suicide research, scientists
said they have pinpointed an area near the front of the brain
where the biochemical activity seems to go awry in people who
commit suicide.
"It's as if people who commit suicide are no longer able to
inhibit their suicidal tendencies and actually are able to go
on and complete the suicide," said Columbia's Victoria
Arango.
The faulty chemical activity may stem from genetic factors,
or upbringing, and when coupled with a psychiatric disorder
or stressful event, may be what pushes the person toward
suicide.
Now, through techniques like this, scientists are trying to
see if they can detect the same abnormality in the brains of
people who are alive.
"We have new imaging technologies that are getting more
precise. They're helping us to localize better areas of the
brain that may be altered in the psychiatric disorders," said
Dr. Mary Blehar, of the National Institute of Mental Health.
In turn, patients' doctors and families could be alerted to
try to prevent suicides.
"We already know from studies of people who've killed
themselves that of the 50 percent who went to the doctor with
major depression, fewer than a quarter received adequate
doses of antidepressants. So we could do a better job of
treating the depression," said Columbia's Mann.
With suicide the third leading cause of death among young
people, mental health experts say identifying those at risk
could finally put a dent in the numbers of those killing
themselves.
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