The vice president's office announced Saturday evening that chief of staff Marc Short was diagnosed with Covid-19. Sources told CNN that Marty Obst, a senior adviser to Pence who is not a government employee, and another aide in Pence's office also tested positive for the virus.
The vice president's office has not commented on Obst or the staffer in Pence's office who tested positive for Covid-19 in recent days.
The developments raise new questions about safety protocols and transparency within the White House as the pandemic has killed more than 224,000 Americans.
Some context: The news comes just over a week before election day amid a blitz of campaign stops for Pence, who leads the White House coronavirus task force, including the vice president's trips to Florida, Indiana, Ohio, Pennsylvania and New Hampshire in the last week.
9:26 a.m. ET, October 25, 2020
Why some voters still have not received their mail-in ballots
From CNN's Annie Grayer
With less than two weeks to go before Election Day, many voters around the country have still not received their mail-in ballots.
Printing errors, mail delivery delays and the sheer volume of requests have left many states across the country scrambling to get ballots into the hands of voters ahead of the fast approaching deadline.
Voters in Ohio have seen delays thanks to a ballot printing backup. In Michigan, a state that has already seen 3 million absentee ballot requests, 20,000 absentee ballots have yet to be sent out. In addition to printing and mail delivery delays, some counties had to reprint and re-send ballots, including Pennsylvania's Allegheny County -- further squeezing the window for voters to get their ballots returned in time.
Voters who say they requested their absentee ballots in a timely fashion are frustrated and confused to find themselves still waiting, just a week before the recommended US Postal Service deadline for getting ballots back in the mail.
Lee Zacharias, 75, from Greensboro, North Carolina, never received her absentee ballot. She wanted to vote via absentee because of her compromised immune system, but ended up risking her health, and voting in-person because she felt that it was getting too close to the deadline.
According to BallotTrax, a new tool North Carolina voters can use to keep up with their ballot status, Zacharias' initial ballot was outbound on September 11. When that one didn't show up, she called the Guilford County Board of Elections on September 28. Zacharias said she was told BallotTrax isn't always accurate, but to be safe the county would cancel her original ballot and send her a new one. When that ballot didn't arrive, Zacharias decided to cast her vote in person because she was nervous that it would never show up.
"The fact that I know that mine is not the only case. That there are a number of other people that have not received absentee ballots they applied for, who had ballots that disappeared, like mine did and have been voided and have not receive replacement ballots makes me angry," Zacharias said.
Read the full story here and visit CNN's Voter Guide to see deadlines in your state.